Thyrotrophin Receptor Antibody: Objective and Quantitative Inflammatory Indicator in Patients With Thyroid Eye Disease
Authors' conclusion
TRAb significantly correlated with both CAS (clinical inflammation indicator) and inflammatory cytokines (pathological inflammation marker). Consequently, we propose, for the first time, that TRAb may serve as an objective and quantitative biomarker for assessing inflammation in TED.
Study context
- Population
- Consecutive patients with thyroid eye disease (TED); 116 females, 110 males, mean age 46.4 ± 12.2 years
- Participants
- 226 consecutive TED patients
- Exposure
- Thyrotrophin receptor antibody (TRAb)-positive vs TRAb-negative
- Outcome
- Whether TRAb can serve as a quantitative, objective indicator of inflammatory status in TED
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Correlation of TRAb with clinical activity score (CAS)
Correlation between TRAb and clinical activity score (CAS) (most pronounced)
r = 0.427
P < .001
Observational data: associations, not effects.
Further findings
Orbital adipose tissue inflammatory cytokines (27 cytokines)
- TRAb significantly positively correlated with 7 proinflammatory cytokines (IL-8, CCL-3, serpin E1, PDGF-AB, IL-12p70, IL-21, PDGF-BB)
- TRAb significantly negatively correlated with 1 anti-inflammatory cytokine (BMP-7)
- IL-8, CCL-3, serpin E1, PDGF-AB and IL-1β significantly upregulated in TRAb-positive vs TRAb-negative; BMP-7 showed the opposite trend
- 41 patients
Change in TRAb and CAS after IV methylprednisolone (IVMP)
- TRAb and CAS significantly decreased after IVMP, with significant correlation between reductions in TRAb and CAS
- 40 patients
Original publication
Thyrotrophin Receptor Antibody: Objective and Quantitative Inflammatory Indicator in Patients With Thyroid Eye Disease. J Clin Endocrinol Metab. Published 9 May 2025. doi:10.
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