The Epidemiology of Thyroid Eye Disease in Olmsted County, Minnesota, 2005–2020
Authors' conclusion
Incidence rates for TED remained stable over the past two decades, yet lower than that in the previous study from our population. Females continue to have the peak incidence rate a decade earlier than males, and the majority of disease burden is present after the age of 50 years.
Study context
- Population
- Adults aged ≥18 years, Olmsted County, Minnesota residents with newly diagnosed thyroid eye disease (TED), 2005–2020, Rochester Epidemiology Project
- Participants
- 83 incident patients
- Exposure
- Females vs Males
- Femalesn = 75
- Outcome
- Incidence rates and point prevalence of TED
Main finding
As reported in the abstract
Incidence of TED
Females
8.9 cases/100,000 person-years
Males
1 case/100,000 person-years
- Overall age and sex adjusted incidence (US population)
- 5 cases/100,000 person-years
- Peak incidence, females, ages 60-64 and 80-84 years
- 18.3 and 18 cases/100,000 person-years
- Peak incidence, males, ages 70-74 years
- 5.7 cases/100,000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | Females | Males | P value |
|---|---|---|---|
| Point prevalence per 100,000 | 114.5 (CI 92.6–139.9) | 13.8 (CI 6.8–24.6) | P < 0.001 |
- Point prevalence per 100,000 — Overall point prevalence per 100,000
- 65 (CI, 53.3-78.7)
Factors associated with disease progression
- Severity of soft tissue involvement, HR
- 7.7 (2-29.8) (CI)
- Presence of diplopia, HR
- 2.5 (1.2-5.1) (CI)
Original publication
The Epidemiology of Thyroid Eye Disease in Olmsted County, Minnesota, 2005–2020. Thyroid. Published 7 October 2024. doi:10.
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