Maternal Thyroid Function and Biochemical Markers of Placental Function in Early Pregnancy
Authors' conclusion
In a large cohort of Danish pregnant women, higher levels of sFlt-1 and PlGF associated with maternal thyroid function in early pregnancy, while there was no association with maternal thyroid autoantibodies.
Study context
- Population
- Pregnant women, North Denmark Region, 2013, with blood samples drawn in early pregnancy
- Participants
- 858 women
- Exposure
- sFlt-1 and placental growth factor (PlGF) percentile levels (<25th, 25–75th, >75th pc) vs maternal thyroid-stimulating hormone (TSH), free thyroxine (fT4) and thyroid autoantibodies
- Outcome
- Association between maternal TSH and fT4 and percentile levels of sFlt-1 and PlGF (adjusted beta coefficient)
- Follow-up
- Early pregnancy
Main finding
As reported in the abstract
Higher sFlt-1 (>75th pc): lower TSH, aβ
0.62
95% CI 0.51–0.76
Higher sFlt-1 (>75th pc): higher fT4, aβ
1.03
95% CI 1.01–1.05
Higher PlGF: lower TSH, aβ
0.82
95% CI 0.69–0.98
Higher PlGF: no association with fT4, aβ
1.00
95% CI 0.97–1.02
Observational data: associations, not effects.
Further findings
Maternal thyroid autoantibodies (thyroid-peroxidase antibodies (TPO-Ab) >60 U/mL or thyroglobulin antibodies (Tg-Ab) >33 U/mL) by sFlt-1 and PlGF pc levels
- No association; TPO-Ab: sFlt-1 p-value 0.5, PlGF p-value 0.1
- No association; Tg-Ab: sFlt-1 p-value 0.7, PlGF p-value 0.1
- Chi-squared test
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →