Biochemical markers of renal function and maternal hypothyroidism in early pregnancy
Authors' conclusion
Reference intervals for CysC and creatinine were dynamic in early pregnancy and decreased with increasing gestational age. Furthermore, higher levels of CysC and creatinine associated with a higher prevalence of maternal autoimmune hypothyroidism. Results encourage considerations on the underlying mechanisms for the association between markers of renal and thyroid function.
Study context
- Population
- Pregnant women in early pregnancy, North Denmark Region Pregnancy Cohort (2011–2015), consecutive serum samples linked to Danish nationwide registers
- Participants
- 1,112 consecutive samples
- Exposure
- Prevalence of maternal hypothyroidism by cystatin C (CysC) and creatinine level
- Outcome
- (i) Pregnancy-specific reference intervals for CysC and creatinine; (ii) prevalence of maternal hypothyroidism in early pregnancy by CysC and creatinine level
- Follow-up
- Early pregnancy
Main finding
As reported in the abstract
CysC <25th; 25th-75th; >75th percentile
1.7%, 3.8%, 7.4%
Creatinine <25th; 25th-75th; >75th percentile
2.5%, 4.1%, 7.1%
Reference intervals (2.5-97.5 percentiles) for CysC, weeks 4-8; 9-11; 12-15
0.58-0.92 mg/L; 0.54-0.91 mg/L; 0.52-0.86 mg/L
Reference intervals (2.5-97.5 percentiles) for creatinine, weeks 4-8; 9-11; 12-15
46.9-73.0 µmol/L; 42.0-68.4 µmol/L; 38.8-66.4 µmol/L
Observational data: associations, not effects.
Original publication
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