Increased Thyroid DPP4 Expression Is Associated With Inflammatory Process in Patients With Hashimoto Thyroiditis
Authors' conclusion
DPP4 expression was significantly increased in the thyroid of the HT group compared with the control group, and was mainly localized in the lymphocytes. Inhibition of lymphocyte DPP4 activity reduced the production of inflammatory factors in co-cultured thyroid cells. Therefore, inhibition of DPP4 may have a beneficial effect by alleviating inflammatory reactions in HT patients.
Study context
- Population
- Drug-naive patients with Hashimoto thyroiditis and control individuals
- Participants
- 40 vs 81
- Comparison
- Hashimoto thyroiditis (HT) vs controls
- HTn = 40
- Controlsn = 81reference
- Outcome
- DPP4 expression and activity in peripheral blood and thyroid tissue
Methodological detailsSingle-cell RNA sequencing (scRNA-seq) analysis of public data set, in vitro cell experiments
- scRNA-seq analysis of public data set
- In vitro cell experiments
Main finding
As reported in the abstract
DPP4 expression and activity
- Similar DPP4 serum concentration and activity in HT vs controls
- Thyroid DPP4 expression and activity significantly increased in HT vs controls
Observational data: associations, not effects.
Further findings
scRNA-seq of 6 para-tumor tissue samples (GSE184362)
- DPP4 expression significantly increased in HT, mainly expressed in T cells
In vitro: lymphocyte DPP4 inhibition with sitagliptin
- Downregulated production of inflammatory factors in co-cultured thyroid cells
Original publication
Increased Thyroid DPP4 Expression Is Associated With Inflammatory Process in Patients With Hashimoto Thyroiditis. J Clin Endocrinol Metab. Published 21 December 2023. doi:10.
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