Maternal hypothyroidism and adverse outcomes of pregnancy
Authors' conclusion
A high frequency of adverse pregnancy outcomes was seen among pregnancies exposed to maternal TSH above 10 mIU/L, whereas no association with thyroid autoantibodies was seen.
Study context
- Population
- Singleton pregnancies, North Denmark Region Pregnancy Cohort (2011–2015); Thyroid stimulating hormone (TSH), TPOAb and thyroglobulin antibodies (Tg-Ab) measured in early pregnancy blood samples
- Participants
- 14,744 singleton pregnancies
- Exposure
- Maternal hypothyroidism (TSH >6.0 or >10 mIU/L) and thyroid autoimmunity vs TSH <6.0 mIU/L / no autoantibodies
- Outcome
- Adverse pregnancy outcomes (spontaneous abortion, preterm birth) by maternal hypothyroidism and thyroid autoimmunity
Main finding
As reported in the abstract
Spontaneous abortion
Each group vs TSH <6.0 mIU/LAdjusted odds ratio (95% CI)
TSH >6.0 mIU/L
1.0(0.5–2.0)
TSH >10 mIU/L
2.0(0.8–5.2)
Observational data: associations, not effects.
Further findings
| Outcome | TSH <6.0 mIU/L | TSH >6.0 mIU/L | TSH >10 mIU/L | aOR (95% CI) | |
|---|---|---|---|---|---|
| Preterm birthTSH >6.0 mIU/Lvs TSH <6.0 mIU/L | 5.4% | 7.8% | 11.4% | 1.5 (0.7–2.9) | |
| Preterm birthTSH >10 mIU/Lvs TSH <6.0 mIU/L | 2.6 (0.9–7.3) | ||||
| 0.10.31310Adjusted odds ratio (log scale) |
Thyroid autoantibodies (TPOAb >60 U/ml, Tg-Ab >33 U/ml) and spontaneous abortion / preterm birth
- TPOAb, spontaneous abortion: aOR
- 1.0 [0.8-1.3] (CI)
- Tg-Ab, spontaneous abortion: aOR
- 1.0 [0.8-1.2] (CI)
- TPOAb, preterm birth: aOR
- 1.0 [0.8-1.2] (CI)
- Tg-Ab, preterm birth: aOR
- 0.9 [0.7-1.2] (CI)
- No association found
Pregnancy outcomes overall
- Live births
- 93.2%
- Spontaneous abortions
- 6.5%
- Stillbirths
- 0.3%
Original publication
Maternal hypothyroidism and adverse outcomes of pregnancy. Clin Endocrinol (Oxf). Published 28 November 2022. doi:10.
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