Are there bidirectional associations between maternal thyroid function and glucose metabolism in singleton live births? A birth cohort study
Authors' conclusion
There was a non-bidirectional association between maternal thyroid function and glucose metabolism during pregnancy. FT4 and TSH levels influence FPG concentrations in the first and second trimesters of pregnancy.
Study context
- Population
- Pregnant women, Ma' anshan Birth Cohort, China; Thyroid-stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb) and fasting plasma glucose (FPG) measured in first, second and third trimesters
- Participants
- 2,375 women
- Outcome
- Bidirectional associations between maternal thyroid function (TSH, FT4, TPOAb) and FPG levels
- Follow-up
- Throughout pregnancy
Methodological detailscross-lagged panel model
- Cross-lagged panel model
Main finding
As reported in the abstract
- FT4 positively correlated with FPG in first trimester and negatively in second trimester
- TSH negatively associated with FPG in second trimester; first-trimester TSH positively predicted second-trimester FPG
- No significant association between TPOAb and FPG during pregnancy
Observational data: associations, not effects.
Original publication
Are there bidirectional associations between maternal thyroid function and glucose metabolism in singleton live births? A birth cohort study. Diabetes Res Clin Pract. Published 8 February 2024. doi:10.
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