Structural and Functional Alterations of Hippocampal Subfields in Patients With Adult-Onset Primary Hypothyroidism
An erratum to this article was published (J Clin Endocrinol Metab, 17 Jun 2024 ↗)
Authors' conclusion
Patients with SCH and OH might be at risk of cognitive decline, anxiety, or depression, and exhibited alterations in volume and FC in specific hippocampal subfields. Furthermore, the reduction in volume was more pronounced in SCH. This study provides novel insights into the neuropathological mechanisms of brain impairment in hypothyroidism.
Study context
- Population
- Patients with newly diagnosed adult-onset primary subclinical hypothyroidism (SCH) or overt hypothyroidism (OH), and well-matched healthy controls
- Participants
- 47 / 40 / 53
- Exposure
- SCH and OH vs healthy controls
- SCHn = 47
- OHn = 40
- Healthy controls (HCs)n = 53reference
- Outcome
- Hippocampal subfield volumes and seed-based functional connectivity (FC)
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
- Volumes of right granule cell molecular layer of the dentate gyrus (GC-ML-DG) head, CA4 and CA3 head reduced in SCH and OH
- Volumes of right molecular layer head, CA1 body, left GC-ML-DG head and CA4 head lower in SCH
- Hippocampal subfield volumes decreased more significantly in SCH than OH
- Seed-based functional connectivity (FC) decreased in SCH but increased in OH vs HCs
Observational data: associations, not effects.
Further findings
Cognitive and emotional scale scores
- SCH and OH exhibited significant alterations in cognitive and emotional scale scores
Correlation of thyroid hormone with FC
- Thyroid hormone negatively correlated with FC values in hypothyroidism
Original publication
Structural and Functional Alterations of Hippocampal Subfields in Patients With Adult-Onset Primary Hypothyroidism. J Clin Endocrinol Metab. Published 7 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →