Hypothyroidism and Risks of All-Cause and Cardiovascular Mortality: A Retrospective Cohort Study of 70,276 Chinese Adults
Authors' conclusion
Overt hypothyroidism was associated with increased mortality, particularly in individuals with diabetes. Subclinical hypothyroidism was associated with increased mortality risk only in younger adults, even at modest TSH elevations.
Study context
- Population
- Adults aged 25 to 84 years undergoing routine health examinations at a large medical center in northern China, 2017–2022359 deaths
- Participants
- 70,276 adults
- Exposure
- Overt hypothyroidism and SCH vs euthyroidism
- Overt hypothyroidismn = 853
- Subclinical hypothyroidismn = 2,436
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 5.1 years (IQR 3.6-6.0)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Overt hypothyroidism vs EuthyroidismHazard ratio (CI)
All-cause mortality
2.01(1.17–3.45)
Cardiovascular mortality
2.70(1.18–6.19)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| All-cause mortality, overt hypothyroidism, by diabetes statusOvert hypothyroidismvs EuthyroidismWith diabetes | 5.45 (2.46–12.07) | P for interaction = 0.045 | |
| All-cause mortality, overt hypothyroidism, by diabetes statusOvert hypothyroidismvs EuthyroidismWithout diabetes | 1.19 (0.56–2.54) | P for interaction = 0.045 | |
| All-cause mortality, SCH, by ageSubclinical hypothyroidismvs EuthyroidismAge <50 years | 3.28 (1.31–8.23) | P for interaction = 0.022 | |
| All-cause mortality, SCH, by ageSubclinical hypothyroidismvs EuthyroidismAge <50 years, TSH <10 mIU/L | 3.36 (1.34–8.43) | ||
| All-cause mortality, SCH, by ageSubclinical hypothyroidismvs EuthyroidismAge 50 to 69 years | 0.32 (0.08–1.31) | P for interaction = 0.022 | |
| All-cause mortality, SCH, by ageSubclinical hypothyroidismvs EuthyroidismAge ≥70 years | 1.00 (0.51–1.98) | P for interaction = 0.022 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Hypothyroidism and Risks of All-Cause and Cardiovascular Mortality: A Retrospective Cohort Study of 70,276 Chinese Adults. Thyroid. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →