Impact of levothyroxine therapy for maternal subclinical and overt hypothyroidism on early child neurodevelopment: A prospective cohort study
Authors' conclusion
Children born with maternal SCH demonstrated slightly lower neuropsychological scores at 6 months to 2 years of age compared to those with maternal OH in the clinical practice. The therapeutic effect of maternal SCH on the child neurodevelopment requires further exploration.
Study context
- Population
- Pregnant women with subclinical hypothyroidism (SCH) or overt hypothyroidism (OH) at the first antenatal visit, January 2012 to December 2013; their childrenin final analysis
- Participants
- 442 women
- Exposure
- Maternal SCH vs maternal OH, both in real-world levothyroxine practice
- SCHn = 194
- OHn = 248reference
- Outcome
- Early child neurodevelopment by Gesell Development Diagnosis Scale (GDDS)
- Follow-up
- 1, 3, 6, 12 and 24 months of age
Main finding
As reported in the abstract
GDDS scores · 6 months to 2 years of age
- Gesell Development Diagnosis Scale (GDDS) scores lower in SCH than OH at 6 months to 2 years of age, confirmed by subgroup and sensitivity analyses
Observational data: associations, not effects.
Further findings
Levothyroxine therapy at first antenatal visit · lower with SCH
P < 0.01
Levothyroxine treatment rate at delivery · similar
P > 0.05
Original publication
Impact of levothyroxine therapy for maternal subclinical and overt hypothyroidism on early child neurodevelopment: A prospective cohort study. Clin Endocrinol (Oxf). Published 20 October 2023. doi:10.
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