Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults
Authors' conclusion
Because TSH levels spontaneously normalized in a large proportion of older adults with subclinical hypothyroidism (also after confirmation by repeat measurement), a third measurement may be recommended before considering treatment.
Study context
- Population
- Community-dwelling adults aged 65+ with SCH from the Netherlands, Switzerland, Ireland and the UK
- Participants
- 2,335 vs 361
- Comparison
- Pretrial population vs In-trial placebo
- Pretrial populationn = 2,335
- In-trial placebon = 361
- Outcome
- Incidence of spontaneous normalization of TSH levels and associations between participant characteristics and normalization
Methodological detailspooled data from pretrial population and in-trial placebo group, randomized, double-blind, placebo-controlled trials (TRUST and IEMO 80-plus)
- Pooled data from pretrial population and in-trial placebo group
- Randomized, double-blind, placebo-controlled trials (TRUST and IEMO 80-plus)
Pooled result
As reported in the abstract
Spontaneous normalization of TSH levels
TSH normalized in the pretrial phase (median follow-up 1 year)
60.8%
TSH normalized in the in-trial phase (after 1 year of follow-up)
39.9%
Further pooled results
- Younger age, female sex, lower initial TSH, higher initial FT4, absence of TPOAb and a follow-up measurement in summer were independent determinants for normalization
Original publication
Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults. J Clin Endocrinol Metab. Published 20 October 2023. doi:10.
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