The Cross-sectional and Longitudinal Association Between Thyroid Function and Depression: A Population-Based Study
An erratum to this article was published (J Clin Endocrinol Metab, 19 Apr 2024 ↗)
Authors' conclusion
We show a cross-sectional association between thyroid (dys)function with depressive symptoms, and a U-shaped association between FT4 and incident depressive events in euthyroid individuals. Our findings suggest an association of thyroid function with the risk of developing depression, albeit small. Reverse causation and additional underlying factors may also contribute to the association.
Study context
- Population
- Population-based cohort; baseline TSH, free thyroxine (FT4), TPOAb and depressive symptoms (Centre for Epidemiologic Studies Depression (CES-D) scale)8,366 with longitudinal data
- Participants
- 9,471 participants
- Outcome
- Depressive symptoms (CES-D) cross-sectionally; incident depressive events longitudinally
Methodological detailscross-sectional and longitudinal analyses
- Cross-sectional and longitudinal analyses
Main finding
As reported in the abstract
B per 1 unit increase of natural log-transformed TSH
−0.07
95% CI −0.11; −0.04
Observational data: associations, not effects.
Further findings
Incident depressive events (longitudinal)
- Incident depressive events
- 1366
- U-shaped association between FT4 and incident depressive events, only in euthyroid participants
Original publication
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