Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes
Authors' conclusion
Suppressed serum TSH levels during the first to early second trimester of pregnancy were not associated with altered maternal or neonatal outcomes.
Study context
- Population
- Pregnant women screened at 11.8 ± 2.4 weeks for TSH, free T4 (FT4) and TPOAb; excluded twin and assisted-reproduction pregnancies, TSH >3.74 mIU/L, severe hyperthyroidism, treated thyroid dysfunction, sampling <6 or >16 weeks
- Participants
- 1,081 women
- Exposure
- Suppressed TSH vs euthyroid controls in early pregnancy
- sTSHn = 36
- Controlsn = 1,045reference
- Outcome
- Prevalence of adverse maternal and neonatal pregnancy outcomes
Methodological detailssingle-centre, logistic regression adjusted for TAI, FT4 and demographic parameters
- Single-centre
- Logistic regression adjusted for TAI, FT4 and demographic parameters
Main finding
As reported in the abstract
Adverse maternal and neonatal pregnancy outcomes
Each group vs controlsEstimate (95% CI)P value
sTSH
aOR (iron deficient anaemia) 1.41(0.64–2.99)
P = 0.385sTSH
aOR (GDM) 1.19(0.44–2.88)
P = 0.713sTSH
aOR (preterm birth) 1.57(0.23–6.22)
P = 0.574sTSH
aOR (low Apgar-1' score) 0.71(0.11–2.67)
P = 0.657Observational data: associations, not effects.
Further findings
Serum TSH
P < 0.001
FT4
P < 0.001
TPOAb positivity (TAI)
P = 0.803
| Outcome | sTSH | Controls |
|---|---|---|
| TRAb positivity | 0 events | — not stated in the abstract |
— not stated in the abstract
Original publication
Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes. Eur Thyroid J. Published 18 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →