Thyroglobulin Antibodies in Women with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis
Pooled result · TgAb positivityResult — go to the resultOdds ratio 1.93 CI 1.27–2.92Authors' conclusion
Women with RPL were significantly more often TgAb-positive than women without RPL.
Study context
- Population
- Women with recurrent pregnancy loss (RPL); studies reporting on thyroglobulin antibodies (TgAbs), PubMed and Embase from inception to April 29, 2023
- Participants
- 6,868 women28 studies
- Comparison
- Women with RPL vs women without RPL
- Outcome
- TgAb positivity in women with RPL vs women without RPL
Methodological detailsrandom-effects model, PRISMA guidelines
- Random-effects model
- PRISMA guidelines
Pooled result
TgAb positivity
Odds ratio
1.93
CI 1.27–2.92
By group
RPL
3.6% to 28%
Without RPL
2.4% to 29%
RPLvs Without RPL
OR 1.93 (CI 1.27–2.92)
As reported in the abstract
Further pooled results
| Outcome | OR (CI) | |
|---|---|---|
| TgAbs and/or TPOAbs positivityI2 = 69% | 2.66 (1.75–4.05) | |
| 0.20.5125Odds ratio (log scale) |
Pregnancy loss in next pregnancy by TgAb positivity
- Studies reporting on next pregnancy outcome
- 4
- OR for pregnancy loss ranged from 0.99 in one study to 10.0 in the other; highly heterogeneous
- Meta-analysis could not be performed
Original publication
Thyroglobulin Antibodies in Women with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis. Thyroid. Published 18 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →