Patient-Reported Satisfaction with Thyroid Hormone Replacement Therapy for Subclinical Hypothyroidism in Older Adults: A Pooled Analysis of Individual Participant Data from Two Randomized Controlled Trials
Authors' conclusion
These pooled data from two RCTs showed no major differences in treatment satisfaction between older adults receiving levothyroxine or placebo.
Study context
- Population
- Community-dwelling adults aged ≥65 years with subclinical hypothyroidism (SCH) (persistent thyrotropin 4.60–19.99 mIU/L for >3 months, normal FT4); median age 74.9 years, 55% women
- Participants
- 536 adults2 RCTs
- Comparison
- Levothyroxine vs placebo
- Outcome
- Treatment satisfaction (Treatment Satisfaction Questionnaire for Medication (TSQM): perceived effectiveness, side effects, convenience, global satisfaction)
- Follow-up
- Final study visit
Methodological detailsrandomized, double-blind, placebo-controlled
- Randomized
- Double-blind
- Placebo-controlled
Pooled result
Global satisfaction (TSQM)
Mean difference
−1.1
CI −4.5 to 2.1
P = 0.48
Between Levothyroxine and Placebo
mean difference −1.1 (CI −4.5 to 2.1); P = 0.48
As reported in the abstract
Further pooled results
Wish to continue medication after the trial · no major differences
P = 0.14
Did not wish to continue
Did not know
| Outcome | Mean difference (CI) | |
|---|---|---|
| Desire to continue medication, subgroup with high hypothyroid symptom burden at baseline · after the trialLevothyroxine users more often desired to continue | −21.1% (−35.6% to −6.5%) | |
| −40−20020Difference (linear scale) |
Thyrotropin level · final visit
- Thyrotropin level: baseline median 5.80 (IQR 5.10-7.00) mIU/L in both groups
Original publication
Patient-Reported Satisfaction with Thyroid Hormone Replacement Therapy for Subclinical Hypothyroidism in Older Adults: A Pooled Analysis of Individual Participant Data from Two Randomized Controlled Trials. Thyroid. Published 3 May 2024. doi:10.
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