Effect of levothyroxine therapy on albuminuria and glomerular function in patients with type 2 diabetes and subclinical Hypothyroidism: a randomized controlled pilot trial
Authors' conclusion
Levothyroxine treatment showed trend toward improving albuminuria and eGFR without reaching statistical significance
Study context
- Population
- Adults with T2D and subclinical hypothyroidism (SCH) on background SGLT2i therapyrandomized 1:1
- Participants
- 60 adults
- Comparison
- Levothyroxine vs no levothyroxine therapy
- Levothyroxinen = 30
- Controln = 30reference
- Primary endpoint
- Changes in urinary albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR)
- Follow-up
- 6 months
Methodological detailsopen-label, pilot, hypothesis generating, 24 and 27 completed follow-up in the treatment and control groups respectively
- Open-label
- Pilot
- Hypothesis generating
- 24 and 27 completed follow-up in the treatment and control groups respectively
Primary result
As reported in the abstract
Change in UACR
Levothyroxine
−13.09
mg/g
Control
31.84
mg/g
Levothyroxine vs ControlDifference, mg/g (95% CI)P value
Per-protocol
−44.93(−77.6 to −12.26)
P = 0.008ITT
−35.61(−77.31 to 6.08)
P = 0.092Further findings
| Outcome | Difference (mL/min/1.73 m²) (95% CI) | P value | |
|---|---|---|---|
| Change in eGFR (co-primary) · 6 monthsBetween Levothyroxine and Control · ITT | 4.65 (−8.3 to 17.6) | P = 0.472 | |
| Change in eGFR (co-primary) · 6 monthsLevothyroxinevs ControlPer-protocol | 7.35 (−1.68 to 16.37) | P = 0.108 | |
| −1001020Difference, mL/min/1.73 m² (linear scale) |
| Outcome | P value |
|---|---|
| TSHITT and PP | P < 0.001 |
TSH
- TSH decreased significantly with levothyroxine vs control
Safety
- No adverse event was reported
Original publication
Effect of levothyroxine therapy on albuminuria and glomerular function in patients with type 2 diabetes and subclinical Hypothyroidism: a randomized controlled pilot trial. Diabetes Res Clin Pract. Published 6 August 2026. doi:10.
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