Psychiatric complications in Graves’ disease
Authors' conclusion
Graves' disease affects patients' mood despite treatment. A previous psychiatric condition, mild eye symptoms, and a younger age increase the vulnerability for long-lasting symptoms and require specific attention.
Study context
- Population
- Women with newly diagnosed GD in Sweden, examined during hyperthyroidism and after 15 months of treatment; registry analyses of all invited patients and all Swedish women diagnosed with hyperthyroidism 2013–2018 vs matched controls
- Participants
- 65 vs 65
- Exposure
- Women with newly diagnosed GD vs matched controls
- GDn = 65
- Controlsn = 65reference
- Outcome
- Depression score (CPRS-AS)
- Follow-up
- During hyperthyroidism
Methodological detailsmatched controls, national population-based registry analyses
- Matched controls
- National population-based registry analyses
Main finding
As reported in the abstract
GD
7.5
median · IQR 5.0–9.5
Controls
1.0
median · IQR 0.5–2.5
P < 0.001
Observational data: associations, not effects.
Further findings
Median
| Outcome | GD | Controls | P value |
|---|---|---|---|
| Anxiety score · during hyperthyroidismHigher in patients | 7.7 (IQR 5.0–11) | 2.5 (IQR 1.0–4.0) | P < 0.001 |
| Depression score · after treatmentHigher in patients | 2.5 (IQR 1.5–5.0) | 1.5 (IQR 0.5–3.5) | P < 0.05 |
| Anxiety score · after treatmentHigher in patients | 4.0 (IQR 2.5–7.5) | 3.0 (IQR 1.5–5.0) | P < 0.05 |
Previous psychiatric comorbidity (registry)
- No increased previous psychiatric comorbidity in GD patients vs controls
- No higher prevalence of psychiatric diagnoses and psychoactive drug prescriptions in included GD patients vs decliners, or in women with hyperthyroidism in 5 years before diagnosis vs matched controls
Anxiety at 15 months by patient characteristics
- More anxiety with previous psychiatric condition, mild eye symptoms and younger age (all p<0.05)
Original publication
Psychiatric complications in Graves’ disease. Eur Thyroid J. Published 1 February 2024. doi:10.
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