Altered Static and Dynamic Brain Functional Topological Organization in Patients With Dysthyroid Optic Neuropathy
Authors' conclusion
Functional network alterations were observed both in DON and non-DON patients, providing novel insights into the underlying neural mechanisms of disease. Functional network properties may be potential biomarkers for reflecting the progression of TAO from non-DON to DON.
Study context
- Population
- Patients with thyroid-associated ophthalmopathy (TAO) with and without dysthyroid optic neuropathy (DON), and healthy controls; grade A tertiary hospital66 TAO patients
- Participants
- 28 / 38 / 30
- Exposure
- TAO with DON vs TAO without DON vs healthy controls
- DONn = 28
- non-DONn = 38
- Healthy controls (HCs)n = 30reference
- Outcome
- Topological properties of functional networks
Methodological detailssingle-centre, resting-state functional MRI, graph theory method
- Single-centre
- Resting-state functional MRI
- Graph theory method
Main finding
As reported in the abstract
- Static: DON had lower global efficiency (Eg), local efficiency, normalized clustering coefficient, small-worldness (σ) and higher characteristic path length (Lp) than HCs
- DON and non-DON both had varying degrees of abnormalities in nodal properties
- DON vs non-DON: abnormal nodal properties in orbitofrontal cortex and visual network (VN)
- Dynamic: DON had higher variance in Eg and Lp than non-DON and HCs
- A strengthened subnetwork with VN as core was identified in DON
Observational data: associations, not effects.
Further findings
Correlation with clinical variables
- Significant correlations between network properties and clinical variables
Diagnostic performance for distinguishing DON
- Combination of static and dynamic network properties had optimal diagnostic performance
Original publication
Altered Static and Dynamic Brain Functional Topological Organization in Patients With Dysthyroid Optic Neuropathy. J Clin Endocrinol Metab. Published 31 January 2024. doi:10.
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