Radiological Activity Score (RAS)—MRI Characteristics in Dysthyroid Optic Neuropathy in a Multi‐Ethnic Thyroid Eye Disease Population
Authors' conclusion
MRI features associated with a higher diagnostic likelihood of DON include significant AC and elevated ADC values. ADC may show reasonable promise in diagnosing and predicting DON.
Study context
- Population
- Patients with Thyroid Eye Disease (TED) over eleven years, all with axial T1-weighted and coronal 3 mm MRI STIR images; multi-ethnic population
- Participants
- 26 vs 516
- Exposure
- TED patients with Dysthyroid Optic Neuropathy (DON) vs without DON
- DONn = 26
- non-DONn = 516reference
- Outcome
- MRI features on coronal images
Methodological detailsanonymised, consecutive cases
- Anonymised
- Consecutive cases
Main finding
As reported in the abstract
Elevated EOMSI
Elevated PMFSI
EOME
AC
- DON vs non-DON: P = 0.001
- DON vs non-DON: P = 0.000
- DON vs non-DON: P = 0.001
- DON vs non-DON: P = 0.000
Observational data: associations, not effects.
Further findings
| Outcome | DON | non-DON | P value |
|---|---|---|---|
| ADC valueADC measured in a subset | average 1373 ± 319 | average 973 ± 237 | P = 0.000 |
Likelihood of DON, univariable regression
- Apical crowding, OR
- 29.1 x p = 0.000
- Apparent Diffusion Coefficient (ADC) value ≥ 1200, OR
- 7.3 x p = 0.000
Likelihood of DON, multivariable regression
- Apical crowding, OR
- 22.1 x (p = 0.000)
- ADC value ≥ 1200, OR
- 3.7 x (p = 0.027)
Original publication
Radiological Activity Score (RAS)—MRI Characteristics in Dysthyroid Optic Neuropathy in a Multi‐Ethnic Thyroid Eye Disease Population. Clin Endocrinol (Oxf). Published 20 May 2025. doi:10.
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