Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure
Authors' conclusion
Untreated SGTF is associated with altered tract-specific microstructural morphology in adolescence, which may be reversible with levothyroxine administration in pregnancy.
Study context
- Population
- Children aged 11–16 years of the CATS study, whose mothers had suboptimal gestational thyroid function (SGTF) randomized to LT4 or no supplementation, or normal GTF; diffusion magnetic resonance imaging (MRI) and quantitative magnetization transfer (qMT) imagingusable diffusion and/or qMT data
- Participants
- 75 children
- Comparison
- Untreated SGTF vs normal GTF vs treated SGTF
- Untreated SGTFn = 19
- Normal GTFn = 21reference
- Optimally treated SGTFn = 18
- Overtreated SGTFn = 17
- Primary endpoint
- Effects of SGTF and its treatment on white matter microstructure
Methodological detailsfollow-up MRI study
- Follow-up MRI study
Primary result
As reported in the abstract
Mean diffusivity within the inferior longitudinal fasciculus
- Untreated SGTF vs Normal GTF: P = 0.007
Further findings
Maternal TSH and FT4 vs white matter microstructure; white matter microstructure vs ADHD symptom scores
- Secondary and exploratory outcomes did not survive corrections for multiple comparisons
Original publication
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure. J Clin Endocrinol Metab. Published 9 May 2025. doi:10.
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