Maternal Thyroid Function During Pregnancy and Offspring White Matter Microstructure in Early Adulthood: A Prospective Birth Cohort Study
Authors' conclusion
Maternal thyroid function in early pregnancy was observed to be associated with WM microstructure in male offspring in early adulthood.
Study context
- Population
- Mother-child pairs; maternal free thyroxine (fT4) and TSH in early gestation; offspring multimodal brain imaging (FA, MD, MTR) of 14 white matter (WM) tracts in early adulthood
- Participants
- 292 mother-child pairs
- Exposure
- Maternal fT4 and TSH in early gestation as predictors of offspring WM microstructure
- Outcome
- Offspring WM integrity: FA, MD and MTR across 14 WM tracts (global analysis)
- Follow-up
- Early adulthood
Methodological detailssex-stratified, linear mixed-effect models, post hoc tract-wise analysis
- Sex-stratified
- Linear mixed-effect models
- Post hoc tract-wise analysis
Main finding
As reported in the abstract
Global FA in males vs maternal fT4
Positive association between maternal fT4 and offspring Global FA in males, fully adjusted (n = 114)
β = 0.154; CI 0.045-0.263
p = 0.006
Observational data: associations, not effects.
Further findings
Tract-wise FA in males
- Finding driven by multiple WM tracts; three projection fiber tracts and the forceps minor survived correction for multiple comparisons
Original publication
Maternal Thyroid Function During Pregnancy and Offspring White Matter Microstructure in Early Adulthood: A Prospective Birth Cohort Study. Thyroid. Published 21 August 2023. doi:10.
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