Maternal Thyroid Function in Early Pregnancy and Offspring School Performance and Neurodevelopmental Disorders
Authors' conclusion
We found no evidence for associations between first trimester maternal thyroid hormone levels and child's school performance, or risk of ADHD or ASD.
Study context
- Population
- Mother-child dyads with first-trimester TSH and FT4 measurements, Copenhagen Primary Care Laboratory Pregnancy Database; children born 2000–2014, followed until end of 2018
- Participants
- 17,909 mother-child dyads
- Exposure
- Associations of first-trimester maternal TSH and FT4 with offspring outcomes
- Outcome
- Child's school performance (standardized test scores), risk of ADHD and ASD
- Follow-up
- Until the end of 2018
Methodological detailsregistry linkage, stratified by preexisting maternal thyroid disorders
- Registry linkage
- Stratified by preexisting maternal thyroid disorders
Main finding
As reported in the abstract
School performance, ADHD and ASD
- No support for an association between maternal thyroid hormone levels and child's school performance (6126 dyads, children born 2000–2009)
- No support for an association between thyroid hormone levels and attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) (17 909 dyads)
- Stratification by preexisting maternal thyroid disorders did not affect the results
- Linear mixed models and Cox regression models
Observational data: associations, not effects.
Original publication
Maternal Thyroid Function in Early Pregnancy and Offspring School Performance and Neurodevelopmental Disorders. J Clin Endocrinol Metab. Published 24 May 2024. doi:10.
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