Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Adolescent Brain Morphology
Authors' conclusion
We found no evidence that SGTF was associated with differences in adolescent brain morphology, and no effect of levothyroxine supplementation.
Study context
- Population
- Children aged 11 to 16 years born to mothers in the CATS study (mothers with suboptimal gestational thyroid function (SGTF) randomly assigned to LT4 or no supplementation from ≈12 weeks' gestation), with usable T1-weighted magnetic resonance imaging (MRI) data85 with usable MRI
- Participants
- 21 / 24 / 21 / 20
- Comparison
- Untreated SGTF vs normal GTF vs treated SGTF
- Untreated SGTFn = 21
- Normal GTFn = 24reference
- Optimally treatedn = 21
- Overtreatedn = 20
- Primary endpoint
- Association of SGTF and its treatment with global brain volumes
Methodological detailsT1-weighted structural MRI, adjusted for age, sex and pubertal scores
- T1-weighted structural MRI
- Adjusted for age, sex and pubertal scores
Primary result
As reported in the abstract
Global brain volumetric measures
- No significant differences in global brain volumetric measures between groups
- Between Untreated SGTF and Normal GTF: P = 0.373
- Adjusted for age, sex and pubertal scores
Further findings
Maternal TSH and free thyroxine (FT4) levels vs global and subregional brain volumes
- Weak positive correlations between maternal TSH, but not FT4, levels and several brain volumes; did not survive testing for multiple comparisons
Original publication
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Adolescent Brain Morphology. J Clin Endocrinol Metab. Published 15 May 2024. doi:10.
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