Outcomes of Patients With Dysthyroid Optic Neuropathy Treated With Intravenous Corticosteroids and/or Orbital Decompression Surgery: A Systematic Review and Meta-analysis
Pooled result · ΔBCVAResult — go to the resultDifference 0.26 LogMARAuthors' conclusion
Based on the results of the present meta-analysis, OD or ivGC + OD may be more effective in improving BCVA and MD and reducing proptosis compared with ivGC. Compared with ivGC alone, ivGC + OD is more effective in improving IOP than ivGC. Although this study improves the hierarchy of evidence in the treatment of DON, additional randomized controlled trials are needed to confirm this conclusion.
Study context
- Population
- Patients with dysthyroid optic neuropathy (DON)17 studies
- Comparison
- ivGC vs orbital decompression (OD) vs ivGC + OD
- Outcome
- Improvement of best corrected visual acuity (ΔBCVA)
Pooled result
ΔBCVA
Difference
0.26 LogMAR
P = 0.007
As reported in the abstract
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| Posttreatment proptosisivGC + OD vs ivGC · improved further with ivGC + OD | difference 3.54 mm | P < 0.01 |
| Posttreatment proptosisOD vs ivGC · improved further with OD | difference 3.00 mm | P < 0.01 |
| Visual field mean deviation (MD)ivGC + OD vs ivGC · improved more with ivGC + OD | difference 5.33 dB | P = 0.002 |
| Intraocular pressure (IOP)ivGC + OD vs ivGC · improved further with ivGC + OD | P = 0.03 |
Original publication
Outcomes of Patients With Dysthyroid Optic Neuropathy Treated With Intravenous Corticosteroids and/or Orbital Decompression Surgery: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 17 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →