Ethnicity, TSH‐Receptor Antibody (TRAb) and Thyrotoxicosis Severity Are Determinants of Neutrophil Count in Newly Diagnosed Hyperthyroidism
Authors' conclusion
Graves' hyperthyroidism is associated with ANC decrease that is greatest when substantially high TRAb and FT4 coexist. ANC is further influenced by ethnicity.
Study context
- Population
- Adults with newly diagnosed hyperthyroidism (August 2020 to July 2025) with concurrently available free thyroxine (FT4), TRAb and absolute neutrophil count (ANC); euthyroid controls
- Participants
- 237 adults
- Exposure
- Graves' disease (GD) vs non-GD hyperthyroidism
- GDn = 152
- non-GDn = 85reference
- Outcome
- Absolute neutrophil count (ANC)
- Follow-up
- Diagnosis
Methodological detailsethnicity-matched control cohort
- Ethnicity-matched control cohort
Main finding
As reported in the abstract
P = 0.045
Observational data: associations, not effects.
Further findings
Low ANC < 2.0 × 10⁹/L
TRAb × FT4 interaction for ANC
- Significant TRAb and FT4 interaction for ANC; higher FT4 associated with lower ANC in high TRAb, but not in TRAb-negative patients
- P < 0.001
ANC by ethnicity
- In hyperthyroidism and controls, Black ethnicities had lower ANC and higher prevalence of low ANC vs Asian or White ethnicities
ANC change in GD with low ANC at diagnosis · upon achieving euthyroidism
- Mean ANC increase 1.14 × 109 (95% CI 0.50-1.77 × 109)
- P = 0.002
Original publication
Ethnicity, TSH‐Receptor Antibody (TRAb) and Thyrotoxicosis Severity Are Determinants of Neutrophil Count in Newly Diagnosed Hyperthyroidism. Clin Endocrinol (Oxf). Published 29 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →