Influence of Preexisting Psychiatric Morbidity on Liothyronine Use in Hypothyroidism: A Swedish Nationwide Cohort Study
Main finding · Liothyronine useResult — go to the resultAdjusted odds ratio 1.90 95% CI 1.83–1.97Authors' conclusion
Patients with a psychiatric history before autoimmune hypothyroidism were more likely to receive liothyronine, especially among those with affective or anxiety morbidity. This may reflect persistent symptoms and affect subsequent decisions in the treatment of hypothyroidism.
Study context
- Population
- All adults in Sweden with autoimmune hypothyroidism initiated on thyroid hormones 2006–2020; National Patient Register and National Prescribed Drug Register44.8% psychiatric history
- Participants
- 353,708 adults
- Exposure
- Preexisting psychiatric morbidity vs no psychiatric history
- Outcome
- Liothyronine use
Methodological detailsnationwide, register-based
- Nationwide
- Register-based
Main finding
As reported in the abstract
Adjusted odds ratio
1.90
95% CI 1.83–1.97
P < 0.001
Psychiatric morbidityvs No psychiatric history
aOR 1.90 (95% CI 1.83–1.97); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Liothyronine use, affective or anxiety morbidityAffective or anxiety morbidityvs No psychiatric history | 1.91 (1.84–1.98) | P < 0.001 | |
| Liothyronine use, psychotic morbidityPsychotic morbidityvs No psychiatric historyNo association | 1.08 (0.98–1.19) | P = 0.11 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Influence of Preexisting Psychiatric Morbidity on Liothyronine Use in Hypothyroidism: A Swedish Nationwide Cohort Study. J Clin Endocrinol Metab. Published 7 June 2025. doi:10.
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