Predictors of Prolonged Euthyroidism After Radioactive Iodine Treatment for Graves’ Disease: A Pilot Study
Authors' conclusion
Patients with Graves' disease who received an actual RAI dose close to the calculated RAI dose achieved prolonged euthyroidism > 12 months if they also took hydroxychloroquine during RAI treatment.
Study context
- Population
- Patients with GD receiving radioactive iodine (RAI), hyperthyroid under antithyroid drugs (ATD) or intolerant of ATD85 analysed
- Participants
- 117 patients
- Outcome
- Prolonged euthyroidism > 12 months after RAI
- Follow-up
- > 12 months
Methodological detailspilot study, stepwise logistic regression, generalized additive models for cut-off values
- Pilot study
- Stepwise logistic regression
- Generalized additive models for cut-off values
Main finding
As reported in the abstract
Outcome after RAI
Prolonged euthyroidism > 12 months
18
21.2%
Remained hyperthyroid with decreased ATD doses
38
44.7%
Permanent hypothyroidism needing long-term levothyroxine
29
34.1%
Observational data: associations, not effects.
Further findings
Predictors of prolonged euthyroidism > 12 months (logistic regression)
- Model AUC (ROC)
- 0.932
- Higher chance with age > 66 years, 33 < age ≤ 66 years, quitting smoking vs nonsmoking or current smoking, 600 < microsomal antibody ≤ 1729 IU/mL, 47% < TBII ≤ 81%, 7 < thyroglobulin antibody ≤ 162 IU/mL, 0.63 < ratio of actual to calculated RAI dose ≤ 1.96, or taking hydroxychloroquine
Original publication
Predictors of Prolonged Euthyroidism After Radioactive Iodine Treatment for Graves’ Disease: A Pilot Study. Endocr Pract. Published 14 November 2022. doi:10.
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