Association Between Maternal Thyroid Hormone Concentration with Normal Thyroid Function During Pregnancy and Preschoolers’ Glycolipid Metabolism: A Birth Cohort Study
Authors' conclusion
Maternal TH dynamic variations may be associated with glycolipid metabolism in preschoolers, even when women do not have clinically diagnosed thyroid disorders.
Study context
- Population
- Mother-child pairs from the Ma'anshan birth cohort; mothers with normal thyroid function during pregnancy; children assessed at 4–6 years
- Participants
- 1,130 mother-child pairs
- Outcome
- Maternal TH and children's glycolipid metabolism
- Follow-up
- Children aged 4-6 years
Methodological detailsBinary logistic, linear and generalized linear regression models; TH trajectories fitted via latent category growth models
- Binary logistic, linear and generalized linear regression models; TH trajectories fitted via latent category growth models
Main finding
As reported in the abstract
children aged 4-6 years
1st trimester maternal T3 and children's blood glucose (positive association), β
0.007
CI 0.028–0.181
1st trimester maternal FT4 and children's blood glucose (positive association), β
0.022
CI 0.004–0.040
1st trimester high FT4 and children's hypercholesterolemia, OR
0.870
CI 0.768–0.986
3rd trimester maternal T4 and children's cholesterol (negative association), β
−0.002
CI −0.003–0.00
Observational data: associations, not effects.
Original publication
Association Between Maternal Thyroid Hormone Concentration with Normal Thyroid Function During Pregnancy and Preschoolers’ Glycolipid Metabolism: A Birth Cohort Study. Thyroid. Published 7 March 2025. doi:10.
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