Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex
An erratum to this article was published (J Clin Endocrinol Metab, 22 Apr 2025 ↗)
Authors' conclusion
Participants with ScTD and euthyroid participants have similar cvRFs and differences are arguably too small to explain the increased cardiovascular risk in ScTD observed in previous studies.
Study context
- Population
- Participants aged 18 to 103 years from 16 international cohorts; mean age 62 years, 55% women, 25% current smokers
- Participants
- 69,006 participants16 cohorts
- Exposure
- Subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) vs euthyroid
- SHypon = 3,748
- SHypern = 3,428
- Outcome
- Cardiovascular risk factors (BP, lipid levels, hs-CRP) by age and sex
Methodological detailsThyroid Studies Collaboration, 16 international cohorts
- Thyroid Studies Collaboration
- 16 international cohorts
Main finding
As reported in the abstract
Cardiovascular risk factors by sex
SHyper vs EuthyroidaMD, mmHg (95% CI)
Diastolic BP, women; lower with SHyper
−1.3(−2.0 to −0.5)
Systolic BP, men; lower with SHyper
−3.1(−4.8 to −1.4)
SHyper vs EuthyroidaMD, mmol/L (95% CI)
LDL-C, women; lower with SHyper
−0.17(−0.29 to −0.05)
Observational data: associations, not effects.
Original publication
Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex. J Clin Endocrinol Metab. Published 12 December 2024. doi:10.
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