Endocrine complications after hematopoietic stem cell transplantation during childhood—Results from a close follow‐up in a cohort of 152 patients
Authors' conclusion
At least one endocrine complication was diagnosed in 65.1% of patients, with gonadal dysfunction being the most prevalent. The conditioning regimen with TBI was a risk factor for the development of several endocrine disorders. This study is one of the largest series evaluating the endocrine disorders among survivors of paediatric HSCT and intends to reinforce the importance of routine follow-up of these patients.
Study context
- Population
- Patients who underwent haematopoietic stem cell transplantation (HSCT) in paediatric age with ≥24 months of follow-up at endocrine late-effects clinics
- Participants
- 152 patients
- Outcome
- Endocrine disorders developed after HSCT
Methodological detailsMedian age at HSCT 7.5 (IQR: 9) years
- Median age at HSCT 7.5 (IQR: 9) years
Main finding
As reported in the abstract
At least one endocrine complication
65.1%
Primary hypogonadism
34.2%
Growth hormone deficiency (GHD)
23.0%
Observational data: associations, not effects.
Further findings
Risk factors for gonadal dysfunction
- Female gender
- P < 0.001
- HSCT > 10 years old
- P = 0.01
- Chemotherapy before HSCT
- P < 0.001
GHD: stature and associations
- Mean stature Z-score at GHD diagnosis
- −1.8 ± 1.4
- GHD associated with cranial
- P < 0.001
- GHD associated with HSCT < 10 years old
- P ≤ 0.001
Disorders with higher risk after total body irradiation (TBI) exposure
- Primary hypothyroidism 22.3%
- P = 0.01
- Thyroid nodules 17.1%
- P < 0.001
- Thyroid carcinoma 5.3%
- P < 0.001
- Dyslipidaemia 19.1%
- P < 0.001
- Disturbance of carbohydrate metabolism 19.1%
- P < 0.001
Original publication
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