Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children
Authors' conclusion
In conclusion, thyroidal hypo- and hyperthyroidism are very rare 3 months after HSCT. These results indicate that surveillance for hypo- and hyperthyroidism may start later in time. The changes in thyroid function parameters found 3 months after HSCT might reflect euthyroid sick syndrome.
Study context
- Population
- Children (<21 years) who underwent allogeneic or autologous hematopoietic stem cell transplantation (HSCT) during a 2-year period, Princess Máxima Center, the Netherlands
- Participants
- 72 children
- Exposure
- Thyroid function before vs 3 months after HSCT
- Outcome
- Thyroidal hypothyroidism or hyperthyroidism 3 months after HSCT
- Follow-up
- 3 months after HSCT
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Thyroidal hypothyroidism or hyperthyroidism
- 0
Observational data: associations, not effects.
Further findings
Aberrant TSH or FT4 concentrations · before and 3 months after HSCT
- Before HSCT
- 16%
- 3 months after HSCT
- 10%
Elevated reverse triiodothyronine (rT3) · before and 3 months after HSCT
- Before HSCT
- 9.3%
- 3 months after HSCT
- 37%
- Could be related to poor physical condition
Individual decline in FT4 concentration of ≥20% · 3 months after HSCT
- Individual FT4 decline ≥20%
- 10.5% (6/57)
Original publication
Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children. Eur J Endocrinol. Published 26 May 2023. doi:10.
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