Genetic determinants of thyroid function in children
Authors' conclusion
The effects of many known thyroid function SNPs are already apparent in childhood and some might be notably larger in children as compared to adults. These findings provide new knowledge about genetic regulation of thyroid function in early life.
Study context
- Population
- Newborns and (pre)school children from 3 population-based prospective cohorts with genetic and thyroid function data (Netherlands, UK, Australia)3 cohorts
- Comparison
- Generation R vs Avon Longitudinal Study of Parents and Children (ALSPAC) vs Brisbane Longitudinal Twin Study (BLTS)
- ALSPACn = 3,382
- BLTSn = 1,680
- Outcome
- Association of previously identified adult TSH and FT4 genetic determinants (SNPs) with TSH and FT4 concentrations
Methodological detailsmeta-analysis of three population-based prospective cohorts, multivariable linear regression, weighted polygenic risk scores
- Meta-analysis of three population-based prospective cohorts
- Multivariable linear regression
- Weighted polygenic risk scores
Pooled result
As reported in the abstract
childhood
Single nucleotide polymorphisms (SNPs) associated with thyroid stimulating hormone (TSH)
30 of 60
SNPs associated with free thyroxine (FT4)
11 of 31
Variability in TSH explained by TSH PRS
5.3%-8.4%
Variability in FT4 explained by FT4 PRS
1.5%-4.2%
Further pooled results
SNP associations with thyroid function in neonates
- TSH SNPs associated with thyroid function in neonates
- Five
- No FT4 SNPs were associated with thyroid function in neonates
Original publication
Genetic determinants of thyroid function in children. Eur J Endocrinol. Published 2 August 2023. doi:10.
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