Polyethylene Glycol (PEG) Precipitation to Detect Macro‐TSH in Clinical Practice: A Systematic Review
Authors' conclusion
PEG precipitation can be taken into account as a useful diagnostic tool for macro-TSH. However, it is necessary to perform PEG precipitation in cases with a highly suspicious clinical picture and at the same time perform all available ancillary tests. PEG-precipitable TSH > 75% can be considered a reliable diagnostic threshold for macro-TSH cases.
Study context
- Population
- Studies of PEG precipitation for detection of macro-thyroid-stimulating hormone (macro-TSH); tertiary centres; newborns to elderly subjects
- Participants
- 4,476 participants23 studies
- Comparison
- Macro-TSH cases vs No-macro-TSH cases
- Outcome
- PEG-precipitable TSH
Methodological detailsPRISMA guidelines, PubMed and Scopus searched up to August 2024, 10 observational studies and 13 case series/reports
- PRISMA guidelines
- PubMed and Scopus searched up to August 2024
- 10 observational studies and 13 case series/reports
Pooled result
As reported in the abstract
Macro-TSH cases
81% to 90%
No-macro-TSH cases (controls)
44.1% to 61.8%
Further pooled results
PEG concentration
- Most evidence achieved with PEG concentrations of 12.5%
Risk of bias
- All studies showed a low risk of bias
Original publication
PEG Precipitation to Detect Macro‐TSH in Clinical Practice: A Systematic Review. Clin Endocrinol (Oxf). Published 19 December 2024. doi:10.
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