Rapid and sensitive bioassay for thyroid-stimulating immunoglobulin detection in thyrotropin-binding inhibitory immunoglobulin–negative euthyroid Graves’ orbitopathy
Authors' conclusion
TSH-R-Ab are not absent in TBII-negative EGO, but require highly sensitive bioassays for detection. In contrast to traditional bioassays, Turbo TSI offers a simple and fast protocol and can therefore facilitate diagnosis in these patients. Euthyroid GO presents with a milder phenotype than hyperthyroid GO.
Study context
- Population
- Patients with thyrotropin-binding inhibitory immunoglobulin (TBII)-negative euthyroid Graves' orbitopathy (euthyroid GO (EGO)); hyperthyroid graves' orbitopathy (GO) controlsbiobank serum in 6
- Participants
- 6 / 6 / 20 / 40
- Comparison
- Turbo TSI bioassay vs bridge-based TSI binding immunoassay in TBII-negative EGO; TBII-negative EGO vs hyperthyroid GO
- Turbo TSIn = 6
- Bridge-based TSI binding immunoassayn = 6reference
- TBII-negative EGOn = 20
- Hyperthyroid GOn = 40reference
- Outcome
- TSH-R-Ab positivity in biobank sera of TBII-negative EGO
Methodological detailscomparison with hyperthyroid GO controls
- Comparison with hyperthyroid GO controls
Performance
As reported in the abstract
Turbo TSI
6
events
Bridge-based TSI binding immunoassay
2
events
Further findings
Clinical characteristics, TBII-negative EGO vs hyperthyroid GO
- TBII-negative EGO presented unilaterally/asymmetrically more often, had a milder and less active phenotype, and required less surgical intervention than hyperthyroid GO
Original publication
Rapid and sensitive bioassay for thyroid-stimulating immunoglobulin detection in thyrotropin-binding inhibitory immunoglobulin–negative euthyroid Graves’ orbitopathy. Eur J Endocrinol. Published 11 October 2025. doi:10.
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