TSH Receptor Antibody Test Utilization Patterns From a National Reference Laboratory: TSHR Antibody (TRAb), Thyroid-stimulating Immunoglobulin (TSI), or Both?
Authors' conclusion
We observed good clinical and analytical agreement between TRAb and TSI assays, suggesting that paired orders for TRAb and TSI are redundant in the assessment of autoimmune-mediated hyperthyroidism. Use of a single test to assess TRAb would be appropriate in most scenarios and may lead to considerable savings of health care dollars.
Study context
- Population
- Patient encounters with TRAb and TSI test orders at a national reference laboratory, for autoimmune-mediated hyperthyroidismover
- Participants
- 189,000 patient encounters
- Exposure
- Paired TRAb and TSI testing
- Outcome
- Frequency of paired orders and qualitative agreement of TRAb/TSI
Methodological detailsnational reference laboratory, chart review subset, cost analysis
- National reference laboratory
- Chart review subset
- Cost analysis
Main finding
As reported in the abstract
| Group | Value | Discordance |
|---|---|---|
| TRAb/TSI-BA | 14.3% | 12.5% (1590) |
| TRAb/TSI-Br | 17.4% | 6.6% (1149) |
Value
TRAb/TSI-BA14.3%
TRAb/TSI-Br17.4%
Discordance
TRAb/TSI-BA12.5% (1590)
TRAb/TSI-Br6.6% (1149)
Observational data: associations, not effects.
Further findings
Clinical correlation (chart review)
- TSI assays aligned better with hyperthyroidism and confirmed GD diagnoses
Cost of paired orders
- Increase in potentially unnecessary testing costs
- 31% to 325%
Original publication
TSH Receptor Antibody Test Utilization Patterns From a National Reference Laboratory: TRAb, TSI, or Both? J Clin Endocrinol Metab. Published 7 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →