Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology
Authors' conclusion
Higher Tg is associated with lower IQ in early childhood and higher thyroid function during pregnancy but not with IQ or brain morphology in later childhood. Further research should determine the value of Tg in addition to UIC for defining iodine status.
Study context
- Population
- Pregnant women and offspring from Generation R (the Netherlands, iodine-sufficient) and INfancia y Medio Ambiente (Spain, mildly iodine-deficient) with maternal thyroglobulin (Tg) and thyroid function data in the first half of pregnancy or in cord blood
- Exposure
- Maternal Tg
- Outcome
- Maternal and newborn thyroid function (TSH, FT4); offspring IQ and brain morphology
- Follow-up
- Early childhood IQ (age 4.5 and 6 years), late childhood IQ (age 9 and 13), brain morphology at 10 years
Methodological details2 population-based prospective cohorts, multivariable linear regression
- 2 population-based prospective cohorts
- Multivariable linear regression
Main finding
As reported in the abstract
Association of maternal Tg with outcomes
Tg and TSH in pregnancy (lower), n = 4367
−0.12
−0.16; −0.08
Tg and free T4 (FT4) in pregnancy (higher), n = 4367
0.08
0.05; 0.12
Tg and IQ in early childhood (lower), β [95% CI], n = 2919
−0.06
−0.10; −0.01
Observational data: associations, not effects.
Further findings
Effect modification by iodine-to-creatinine ratio; adjustment for thyroid function
- No association differed by iodine-to-creatinine ratio or changed when adjusted for thyroid function
Original publication
Association of Maternal Thyroglobulin With Gestational Thyroid Function and Offspring IQ and Brain Morphology. J Clin Endocrinol Metab. Published 27 September 2024. doi:10.
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