Establishing Serum Thyroglobulin Reference Values and Predictors of Its Variability in an Iodine-Sufficient Population
Authors' conclusion
Population-specific RVs for Tg are essential in clinical decision-making. Known clinical/biochemical variables explained only a small proportion of Tg variability. Our findings underscore the need to identify additional determinants of Tg levels.
Study context
- Population
- Volunteers in an iodine-sufficient population screened by history, physical examination, thyroid function tests, urine iodine excretion and thyroid USvolunteers screened
- Participants
- 420 volunteers
- Exposure
- Cohort 1 vs Cohort 2
- Cohort 1n = 140
- Cohort 2n = 154
- Outcome
- Serum Tg reference values (NACB criteria) and determinants of serum Tg levels
Methodological detailsNational Academy of Clinical Biochemistry (NACB) criteria-based reference value determination, Redundancy Analysis and Variation Partition
- NACB criteria-based reference value determination
- Redundancy Analysis and Variation Partition
Main finding
As reported in the abstract
Tg reference values (NACB criteria; mean ± 2 SD on log-transformed data)
Thyroglobulin (Tg) reference values per NACB criteria
2.95-56.23 ng/mL
Tg reference values suggested by the assay manufacturer
3.5-77 ng/mL
Observational data: associations, not effects.
Further findings
Subgroup analysis of Tg determinants
- TSH had a minor impact only in men; age and gender were not significant contributors
Original publication
Establishing Serum Thyroglobulin Reference Values and Predictors of Its Variability in an Iodine-Sufficient Population. Endocr Pract. Published 25 June 2025. doi:10.
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