New Reference Values for Thyroid Volume by Ultrasound in German Children and Adolescents From a Population-Based Study
Authors' conclusion
The reference values provided by the WHO are overly conservative for this population and could potentially apply to other European countries with a similar history of iodine supply.
Study context
- Population
- Thyroid-healthy German children and adolescents aged 6 to 17 years, baseline of nationwide KiGGS study (2003–2006); sample iodine-sufficient by World Health Organization (WHO) criteria2,509 girls [45.1%]
- Participants
- 5,559 children
- Exposure
- Derived reference values vs WHO 2004 reference values for thyroid volume
- Girlsn = 2,509
- Outcome
- Sex-specific reference values for total thyroid volume (Tvol) by ultrasound, by age and body surface area
Methodological detailsnationwide, lambda-mu-sigma method, KiGGS baseline assessment, 2003–2006
- Nationwide
- Lambda-mu-sigma method
- KiGGS baseline assessment, 2003–2006
Main finding
As reported in the abstract
97th percentile of Tvol vs corresponding WHO reference values (average excess)
Observational data: associations, not effects.
Original publication
New Reference Values for Thyroid Volume by Ultrasound in German Children and Adolescents From a Population-Based Study. J Clin Endocrinol Metab. Published 26 March 2024. doi:10.
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