Association of COVID-19 Infection with Subsequent Thyroid Dysfunction: An International Population-Based Propensity Score Matched Analysis
Main finding · Thyroid dysfunctionResult — go to the resultHazard ratio 2.07 95% CI 2.01–2.12Authors' conclusion
COVID-19 infection was associated with an increased risk of thyroid dysfunction, including thyrotoxicosis and hypothyroidism, regardless of age or sex, during a 12-month follow-up period.
Study context
- Population
- Patients in the TriNetX international electronic health records database; matched for age, sex, race and comorbiditiesbefore matching
- Participants
- 1,379,311 vs 6,896,814
- Exposure
- COVID-19 vs no COVID-19
- COVID-19n = 1,379,311
- Non-COVID-19n = 6,896,814reference
- Outcome
- Diagnosis of thyroid dysfunction (thyrotoxicosis or hypothyroidism), analysed by hazard ratios (HRs) and Kaplan-Meier curves, stratified by age and sex
- Follow-up
- Within 12 months
Methodological detailspropensity score matched, international, population-based
- Propensity score matched
- International
- Population-based
Main finding
Thyroid dysfunction · 3 months postexposure
Hazard ratio
2.07
95% CI 2.01–2.12
COVID-19vs Non-COVID-19
HR 2.07 (95% CI 2.01–2.12)
As reported in the abstract
- Increased risk persisted up to 12 months: overall thyroid dysfunction, fold increased risk
- ∼2.01
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Thyrotoxicosis and hypothyroidism (short term) · 3 months postexposureCOVID-19vs Non-COVID-19 | HR (thyrotoxicosis) 2.10 (CI 1.92–2.29) | |
| Thyrotoxicosis and hypothyroidism (short term) · 3 months postexposureCOVID-19vs Non-COVID-19 | HR (hypothyroidism) 2.08 (CI 2.01–2.13) | |
| 0.512Ratio (log scale) |
Thyroid dysfunction by age subgroup
- Age ≥65 years: HR
- 2.18 (CI 2.11-2.25)
- Age <65 years: HR
- 1.97 (CI 1.91-2.03)
- Subgroup analysis
Thyroid dysfunction by sex subgroup
- Females: HR
- 2.12 (CI 2.06-2.16)
- Males: HR
- 1.76 (CI 1.69-1.82)
- Subgroup analysis
Thyrotoxicosis and hypothyroidism (long term) · up to 12 months
- Increased risk for thyrotoxicosis
- 1.8-fold
- Increased risk for hypothyroidism
- 2.04-fold
Original publication
Association of COVID-19 Infection with Subsequent Thyroid Dysfunction: An International Population-Based Propensity Score Matched Analysis. Thyroid. Published 20 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →