Impact of Hypothyroidism on Short-Term and Long-Term Outcomes of Coronary Artery Bypass Graft Surgery
Main finding · Incidence of CABGResult — go to the resultHazard ratio 1.08 CI 1.03–1.14Authors' conclusion
Hypothyroidism is associated with a higher incidence of coronary disease requiring CABG and increased risks of postoperative complications, heart failure, stroke, and MACE.
Study context
- Population
- Patients with hypothyroidism on thyroid hormone replacement vs controls without thyroid disease; Coronary artery bypass grafting (CABG) outcomes in a propensity-matched subset, TriNetX database6,557 matched post-CABG
- Participants
- 1.23 million patients
- Exposure
- Hypothyroidism vs controls without thyroid disease
- Outcome
- Incidence of CABG
- Follow-up
- 20 years
Methodological detailslongitudinal, TriNetX Global Collaborative Network database, 1:1 propensity score-matching
- Longitudinal
- TriNetX Global Collaborative Network database
- 1:1 propensity score-matching
Main finding
As reported in the abstract
Hazard ratio
1.08
CI 1.03–1.14
By group
Hypothyroidismvs Controls
HR 1.08 (CI 1.03–1.14)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Long-term incident HF after CABG · long-term follow-upPropensity score-matched | 1.15 (1.04–1.28) | |
| Long-term stroke after CABG · long-term follow-upPropensity score-matched | 1.18 (1.01–1.39) | |
| Long-term MACE after CABG · long-term follow-upPropensity score-matched | 1.15 (1.01–1.29) | |
| Critical care utilization after CABG · short-termPropensity score-matched | 1.14 (1.07–1.21) | |
| 0.512Hazard ratio (log scale) |
Sensitivity analysis: abnormal preoperative thyroid-stimulating hormone (TSH) in hypothyroidism
- Abnormal preoperative TSH, particularly elevated TSH, had a higher risk of short-term mortality and long-term embolic events
Safety
| Outcome | HR (CI) | |
|---|---|---|
| Short-term postsurgical infectionsPropensity score-matched | 1.10 (1.01–1.20) | |
| CABG-specific complications · short-termPropensity score-matched | 1.24 (1.08–1.42) | |
| 0.512Hazard ratio (log scale) |
Original publication
Impact of Hypothyroidism on Short-Term and Long-Term Outcomes of Coronary Artery Bypass Graft Surgery. Thyroid. Published 13 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →