Thyroxine Treatment of Adult RTHα Patients: Safety, Efficacy, and Metabolomic Changes
Authors' conclusion
L-T4 treatment of adult RTHα patients was safe and improved QoL in adherent patients.
Study context
- Population
- Adult patients with resistance to thyroid hormone alpha (RTHα), Ala263Val
- Participants
- 4 patients
- Outcome
- Efficacy and biochemical changes on LT4
- Follow-up
- 3 years
Main finding
As reported in the abstract
- FT4, FT3 and rT3 increased to supraphysiological concentrations (relative to reference intervals); TSH suppressed
- Heart rate, bone markers and SHBG transiently increased
- Several classes of lipids reduced
- Bone mineral density (BMD) appeared unaltered
- Patients reported improved quality of life (QoL) (ThyPro)
Safety
- Short non-sustained ventricular tachycardia on L-T3 + LT4
- 1 patient
- No adverse effects on LT4
Original publication
Thyroxine Treatment of Adult RTHα Patients: Safety, Efficacy, and Metabolomic Changes. Thyroid. Published 11 June 2026. doi:10.
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