Increased Risk of Venous Thromboembolism in Patients With Thyroid Eye Disease Compared to Graves’ Disease Without Orbitopathy
Main finding · Incident VTEResult — go to the resultHazard ratio 1.20 95% CI 1.05–1.37Authors' conclusion
TED is associated with increased systemic thrombotic risk independent of traditional VTE risk factors. These findings highlight the systemic implications of TED and suggest that thrombotic risk should be considered in the clinical evaluation and management of affected patients.
Study context
- Population
- Adults with thyroid eye disease (TED) or GD without TED, TriNetX Global Collaborative Network; matched on demographics, comorbidities, medications and BMImatched cohort
- Participants
- 19,320 vs 19,320
- Exposure
- TED vs GD without TED
- TEDn = 19,320
- Graves' disease without TEDn = 19,320reference
- Outcome
- Incident venous thromboembolism (VTE) (PE or DVT) after the index date
- Follow-up
- Mean 4.7 years
Methodological detailspropensity score-matched, 1:1 matching
- Propensity score-matched
- 1:1 matching
Main finding
Incident VTE
Hazard ratio
1.20
95% CI 1.05–1.37
P = 0.007
By group
TEDvs GD without TED
HR 1.20 (95% CI 1.05–1.37); P = 0.007
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | TED | HR (95% CI) | P value | |
|---|---|---|---|---|
| PETEDvs GD without TED | 1.4% | 1.22 (1.02–1.47) | P = 0.03 | |
| 0.512Hazard ratio (log scale) |
- PE: GD without TED 1.1%
DVT and retinal vein occlusion
- Associations with DVT and retinal vein occlusion not statistically significant
Original publication
Increased Risk of Venous Thromboembolism in Patients With Thyroid Eye Disease Compared to Graves’ Disease Without Orbitopathy. Endocr Pract. Published 3 June 2026. doi:10.
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