Association of Thyroid Hormone Medication Adherence With Risk of Dementia
Main finding · Overall dementiaResult — go to the resultAdjusted hazard ratio 0.86 95% CI 0.76–0.97Authors' conclusion
Better adherence to thyroid hormone medication may be beneficial in preventing incident dementia, especially Alzheimer disease, in older adults with newly diagnosed hypothyroidism. Along with the resolution of hypothyroid symptoms and the reduction of cardiovascular risk factors, the reduction of dementia risk may be another potential benefit of thyroid hormone medication.
Study context
- Population
- Older adults aged ≥50 years with newly diagnosed hypothyroidism (2004–2008) who underwent health screening; 87.5% women2,120 incident dementia
- Participants
- 41,554 adults
- Exposure
- Higher vs lower thyroid hormone medication adherence
- Outcome
- Incident dementia
- Follow-up
- Until dementia, death or December 31, 2020
Methodological detailsmultivariable-adjusted Cox proportional hazards regression
- Multivariable-adjusted Cox proportional hazards regression
Main finding
Overall dementia
Adjusted hazard ratio
0.86
95% CI 0.76–0.97
Q4 MPRvs Q1 MPR
aHR 0.86 (95% CI 0.76–0.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Alzheimer disease, MPR ≥0.8vs <0.8 | 0.91 (0.84–0.99) | |
| 0.512Adjusted hazard ratio (log scale) |
Vascular dementia
- No consistent association between thyroid hormone medication adherence and vascular dementia
Original publication
Association of Thyroid Hormone Medication Adherence With Risk of Dementia. J Clin Endocrinol Metab. Published 29 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →