Autoimmune thyroiditis in paediatric thyroid cancer: clinical features and outcomes
Authors' conclusion
AIT was present in 16% of paedDTC patients and was associated with reduced distant metastasis. A tendency toward improved EFS but similar OS during the follow-up period was observed. Earlier detection through surveillance in AIT patients may contribute to these findings, warranting further investigation into underlying biological mechanisms.
Study context
- Population
- Paediatric patients (<18 years) with histopathologically confirmed DTC, German Malignant Endocrine Tumour Registry, 1997–2024evaluable
- Participants
- 401 patients
- Exposure
- PaedDTC with autoimmune thyroiditis (AIT) vs without AIT
- Outcome
- Distant metastasis
Methodological detailsprospectively enrolled registry
- Prospectively enrolled registry
Main finding
As reported in the abstract
P = 0.014
- AIT prevalence
- 16.0%
Observational data: associations, not effects.
Further findings
Event-free survival · study period · tendency toward improved EFS with AIT · Kaplan-Meier estimates
P = 0.255
Overall survival · study period · comparable · Kaplan-Meier estimates
P = 0.167
PaedDTC diagnosed through surveillance (known AIT history) · significantly more frequent with AIT
P = 0.022
- Age at diagnosis · significantly older with AIT
- P < 0.001
- Female predominance · non-significant tendency toward higher with AIT
- P = 0.098
Tumour size, capsule invasion, lymphatic or vascular invasion, soft tissue infiltration, multifocality
- No significant differences
Original publication
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