Incidence and Temporal Patterns of Differentiated Thyroid Carcinoma in Children and Adolescents in Germany: A Pooled Analysis Based on Data from the German Malignant Endocrine Tumor Registry and the German Childhood Cancer Registry
Authors' conclusion
Our study revealed a significant increase in pediatric DTC incidence in Germany, most pronounced among adolescents.
Study context
- Population
- Children and adolescents diagnosed with differentiated thyroid carcinoma (DTC) at ages 0–17 years between 1997 and 2021 in Germany, recorded in the German Malignant Endocrine Tumor (MET) Registry and/or the German Childhood Cancer Registry (GCCR)
- Participants
- 469 DTC cases
- Outcome
- Age-specific and age-standardized incidence rates (ASR) over time and average annual percentage changes (AAPC)
- Follow-up
- 1997-2021
Methodological detailspopulation-based, pooled registry data, 25-year period
- Population-based
- Pooled registry data
- 25-year period
Main finding
As reported in the abstract
ASR of pediatric DTC
- Average ASR, 1997-2021
- 1.16 per million
- ASR, females vs males
- 1.64 vs. 0.72 per million
- Overall ASR, 1997-2001
- 0.84 per million
- Overall ASR, 2017-2021
- 1.48 per million
- Average annual percentage changes (AAPC)
- 3.46% (CI: 2.12-4.83)
Observational data: associations, not effects.
Further findings
Histology
- PTC
- 85.7%
- FTC
- 9.4%
Incidence trend in adolescents aged 15-17 years
- AAPC (CI: 4.43-9.19); increase most pronounced
- 6.79%
Proportion of incidentalomas
- 1997-2001
- 5%
- 2017-2021
- 26%
- No marked shift in tumor size between symptomatic and incidental cases
Original publication
Incidence and Temporal Patterns of Differentiated Thyroid Carcinoma in Children and Adolescents in Germany: A Pooled Analysis Based on Data from the German Malignant Endocrine Tumor Registry and the German Childhood Cancer Registry. Thyroid. Published 30 October 2024. doi:10.
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