Subsequent Thyroid Carcinomas in Children and Adolescents Registered in the German MET Consortium (1997–2023)
Authors' conclusion
Presenting features of subsequent DTCs differ from primary counterparts, although the prognosis is not significantly different. Subsequent DTCs following chemotherapy only versus chemo- and radiotherapy DTCs were larger and diagnosed in younger patients after a shorter latency.
Study context
- Population
- Children and adolescents <18 years with DTC registered with the German Malignant Endocrine Tumor studies (1997–2023)
- Participants
- 505 children
- Exposure
- Subsequent DTC vs first primary DTC; within subsequent DTC, chemotherapy only vs chemo- and radiotherapy
- Subsequent DTCn = 66
- Chemotherapy onlyn = 18
- Outcome
- Subsequent DTC: proportion and characteristics
Methodological detailsnational multicenter registry
- National multicenter registry
Main finding
As reported in the abstract
- Subsequent Differentiated Thyroid Carcinomas (DTCs) among all DTCs
- 66 (13.1%)
- Median age at subsequent DTC diagnosis
- 12.7 years (range, 5.1-17.9)
- Median latency from first malignancy or hematopoietic stem cell transplantation (HSCT)
- 7.3 years (range, 2.2-15.6)
- 5-year overall survival (OS) from subsequent DTC diagnosis
- 100.0%
- 5-year thyroid-related adverse event-free survival (EFS) from subsequent DTC diagnosis
- 82.5%
Observational data: associations, not effects.
Further findings
- Median latency, chemotherapy only vs chemo- and radiotherapy (shorter with chemotherapy only)
- 6.2 vs. 7.8 years
- Median size, chemotherapy only vs chemo- and radiotherapy (larger with chemotherapy only)
- 1.86 vs. 1.18 cm
- Median age at diagnosis, chemotherapy only vs chemo- and radiotherapy (younger with chemotherapy only)
- 11.5 vs. 13.7 years
- No differences observed for OS and EFS
Original publication
Subsequent Thyroid Carcinomas in Children and Adolescents Registered in the German MET Consortium (1997–2023). Thyroid. Published 19 December 2024. doi:10.
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