Long-Term Thyroid Toxicity Burden in Children Who Received Treatment for High-Risk Neuroblastoma
Authors' conclusion
The high cumulative treatment burden in this population results in a substantial risk of thyroid toxicity, even many years after therapy. Therefore, long-term endocrine follow-up should be considered also during adulthood.
Study context
- Population
- High-risk neuroblastoma survivors alive on June 1, 2023, at least 5 years from diagnosis, treated 1996–2018
- Participants
- 45 participants
- Outcome
- Long-term thyroid toxicity
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Long-term thyroid toxicities
24 of 45
53%
Median time to thyroid toxicity from diagnosis
7.5 years
range 1.2–18.2; interquartile range 3–12
Hypothyroidism, most common toxicity
12/24, 50%
Probability free from thyroid toxicity at 10 years
62%
CI: 44–75%
Observational data: associations, not effects.
Further findings
Molecular radiotherapy vs No molecular radiotherapy
| Outcome | Molecular radiotherapy | No molecular radiotherapy | P value |
|---|---|---|---|
| Probability free from thyroid toxicity at 10 years by molecular radiotherapy | 0% | 72% (CI 53–85%) | P < 0.001 |
Immunotherapy vs No immunotherapy
| Outcome | Immunotherapy | No immunotherapy | P value |
|---|---|---|---|
| Probability free from thyroid toxicity at 10 years by immunotherapy | 30% (CI 6–59%) | 78% (CI 65–90%) | P = 0.008 |
Tandem MAT vs Single MAT
| Outcome | Tandem MAT | Single MAT | P value |
|---|---|---|---|
| Probability free from thyroid toxicity at 10 years by MAT | 37% (CI 12–64%) | 71% (CI 49–85%) | P = 0.016 |
Busulfan vs No Busulfan
| Outcome | No Busulfan | Busulfan | P value |
|---|---|---|---|
| Probability free from thyroid toxicity at 10 years by Busulfan | 86% (CI 39–98%) | 55% (CI 35–71%) | P = 0.002 |
Time to thyroid toxicity
- Immunotherapy, 131I-meta-iodobenzylguanidine therapy or Busulfan: thyroid toxicity significantly earlier than those who did not
- P = 0.047
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →