The Incidence of Cardiovascular Disease Events in Women with Hypothyroidism: The Study of Women’s Health Across the Nation
Main finding · Composite CVD eventsResult — go to the resultHazard ratio 0.85 CI 0.55–1.31Authors' conclusion
In a diverse sample of women with long-term follow-up through the menopause transition, we observed no difference in the risk of CVD events between women receiving LT4 treatment for hypothyroidism compared with women without thyroid disease.
Study context
- Population
- Diverse cohort of midlife women from seven US sites (Study of Women's Health Across the Nation), followed from midlife to early old age, up to 17 follow-up visits
- Participants
- 2,647 participants
- Exposure
- Levothyroxine (LT4) treatment vs no thyroid disease
- LT4n = 421
- Outcome
- First composite CVD event:
- Fatal or nonfatal MI
- Stroke
- HF
- Percutaneous coronary intervention
- Coronary artery bypass graft surgery
Methodological detailsmultisite, time-varying exposure
- Multisite
- Time-varying exposure
Main finding
Composite CVD events
Hazard ratio
0.85
CI 0.55–1.31
P = 0.463
Events by group
LT4vs Without thyroid disease
HR 0.85 (CI 0.55–1.31); P = 0.463
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) events in LT4 group stratified by baseline TSH (sensitivity analysis)
- No significant relation after stratification by baseline TSH level
Original publication
The Incidence of Cardiovascular Disease Events in Women with Hypothyroidism: The Study of Women’s Health Across the Nation. Thyroid. Published 24 February 2026. doi:10.
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