Weight Gain after Treatment of Hyperthyroidism is Associated with Impairment of Quality of Life
Authors' conclusion
Our study suggests that weight gain after treatment of hyperthyroidism is associated with a large adverse effect on QoL, with reduced scores on appearance, combined "tiredness and overall QoL" domains of the ThyPRO questionnaire. Management of weight change upon treatment of hyperthyroidism merits further clinical attention and research.
Study context
- Population
- Patients with treated hyperthyroidism 6 months to 8 years after diagnosis; 63% female, mean age 50 years
- Participants
- 108 patients
- Exposure
- Association of percentage weight gain (PWG) after hyperthyroidism treatment with quality of life (QoL) (ThyPRO)
- Outcome
- Whether percentage weight gain (PWG) after treatment of hyperthyroidism was associated with QoL impairment
Methodological detailsprospectively completed database for anthropometric measurements, generalized linear model
- Prospectively completed database for anthropometric measurements
- Generalized linear model
Main finding
As reported in the abstract
PWG and "cosmetic complaints": OR (logistic regression)
1.11
p = 0.008
PWG and "cosmetic complaints": b (generalized linear model (GLM))
0.47, p = 0.022, q (adjusted p) = 0.033
PWG and "tiredness and overall QoL": b (GLM)
0.62, p = 0.011, q = 0.017
PWG not associated with "anxiety and depressivity": b
−0.005
p = 0.661
Observational data: associations, not effects.
Further findings
Weight and BMI at diagnosis vs final evaluation
- Median weight at diagnosis (IQR)
- 65.5 (58.7, 75.5) kg
- Median weight at final evaluation (IQR)
- 72.7 (64.1, 83.8) kg (p < 0.001)
- Median BMI at diagnosis (IQR)
- 23.9 (21.9, 27.1) kg/m²
- Median BMI at final evaluation (IQR)
- 26.5 (23.9, 30.8) kg/m² (p < 0.001)
- Mean (SD) weight gain
- 7.2 (6.2) kg
- Mean (SD) disease duration
- 41 (22.5) months
- Median PWG (IQR)
- 8.8% (4.3%, 17%)
QoL vs general population normative data
- Significantly reduced QoL in all comparable domains vs general population normative data
Original publication
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