A Preclinical State of Graves' Ophthalmopathy Characterized by Hypoxia of T-cells Identified via Multiomics Analysis
Authors' conclusion
The pre-GO state was identified from GH and GO and characterized by upregulation of the hypoxia pathway that may promote effector CD4+ T-cells differentiation. These findings provide new insight into the pathogenesis and prevention of GO.
Study context
- Population
- Patients with Graves' hyperthyroidism, preclinical Graves' ophthalmopathy or Graves' ophthalmopathy
- Participants
- 24 / 10 / 21
- Comparison
- Graves' hyperthyroidism (GH) vs pre-GO vs GO
- GHn = 24
- pre-GOn = 10
- GOn = 21
- Outcome
- Differential expression and methylation; discrimination of pre-GO
Methodological detailsmultiomics analysis, transcription and DNA methylation profiling of PBMCs, in vitro flow cytometry verification
- Multiomics analysis
- Transcription and DNA methylation profiling of PBMCs
- In vitro flow cytometry verification
Main finding
As reported in the abstract
Differentially expressed genes (DEGs), GH vs GO / pre-GO vs GO / GH vs pre-GO
731, 1214, and 372
Differentially methylated CpG sites (DMCs), GH vs GO / pre-GO vs GO / GH vs pre-GO
1583, 277, and 555
DIABLO discrimination of pre-GO via 17 DMC features, ROC
0.9975
DIABLO discrimination of pre-GO via 11 DEG features, ROC
0.9407
Original publication
A Preclinical State of Graves' Ophthalmopathy Characterized by Hypoxia of T-cells Identified via Multiomics Analysis. J Clin Endocrinol Metab. Published 11 April 2025. doi:10.
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